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Purified water in the pharmaceutical industry is often disinfected

2019年8月3日

3

巴氏杀菌

纯化水系统的巴氏灭菌主要涉及将储存和分配系统中的纯净水加热到80℃,然后在此温度下循环1〜2H,以完成纯净水的存储和分配系统的消毒。加热对象巴氏灭菌是纯净的水,没有外部媒体和高安全性。纯净水的量对供暖时间,蒸汽消耗和系统操作安全性具有很大的影响,因此在加热之前需要控制储罐中的水量如果水太多,加热时间和蒸汽消耗将增加,增加运营成本。如果太少,当纯净的水加热时,很容易引起循环泵的气液并损坏循环泵的密封。巴氏杀菌的方法是储罐夹克加热和热交换器加热。由于储罐加热的长时间和温度均匀性,热交换器的加热主要在新建的系统中采用。PASTEURIZER主要控制加热和纯净水的温度,这很方便,可用于检测,高精度,简单的控制过程和稳定因此,巴氏杀菌是纯净水的存储和分配系统中最广泛使用的消毒方法。由于纯化的水在巴氏杀菌过程中用工业蒸汽加热,其在某些工作室中的使用在没有工业蒸汽的情况下受到限制。需要加热和冷却,这需要很长时间(约4小时)。


臭氧消毒

臭氧消毒has just started in recent years.Ozone (O3) is a colorless broad-spectrum fungicide, which has a strong inactivation effect on bacteria, bacterial spores, viruses, fungi, etc., and a relatively large solubility in water, so it has a better disinfection effect in purified water system.Ozone, as a strong oxidant, will damage the non-metal in the system to some extent. If leakage occurs, it will damage the atmosphere and human body.The half-life of ozone is relatively short and easy to decompose, so it puts forward high requirements for the detection of ozone concentration in ozone generator and system.Ozone generator (water electrolysis) and detection instrument prices are high, and the need to add the uv lamp digestion of ozone in the system, the increase in the vent ozone smog breaker, even at the use of the workshop to install automatic valve (with the ozone interlock, to prevent water containing ozone into use, cause harm to the environment and human body), so the investment system will have larger ascension.At present, the main methods of generating ozone in China are discharge method and hydropower method. Among them, the ozone generated by discharge method has a relatively low purity (brought into the air), which will have a certain impact on the system. It is mainly used in some domestic small enterprises.At present, hydropower is a relatively recognized ozone production method used for disinfection of purified water system at home and abroad. Purified water is used as raw material to produce ozone. There is no pollution from outside the system, but the equipment price is relatively high.The penetration rate is not high.


紫外消毒

紫外线辐射具有杀菌作用。但是,纯化的水系统的使用将受到波长,管道水速度,水质变化,灯功率变化,水温和其他因素的影响,这些因素无法完全取代系统的周期性消毒。作为对其他消毒方法的补充,它可以延长系统的消毒期并降低系统的运行成本。目前,一些家庭系统在紫外线灯后添加过滤器,以确保杀死的细菌不会流入下游系统中,但是这种方式将增加过滤器中细菌繁殖和积累的风险,从而导致系统中水质的恶化。因此,在纯化的水系统中安装过滤器不合适。


纯蒸汽的消毒

纯蒸汽灭菌主要用于通过高温(121℃)在系统中灭活微生物。灭菌效果很好,周期很短。系统中的设备和仪器需要承受温度和压力。在系统的所有低点,需要陷阱和温度检测设备来保持系统的温暖,从而增加了系统设备的投资。在中国的早期系统中,某些系统将直接进入纯蒸汽,然后在直接排水系统(纯蒸汽放电端口不安装蒸汽陷阱),通过系统末端的蒸汽形成所谓的循环蒸汽。此方案在系统的末端和低点没有检测和控制装置,这在过程中是不稳定的,安全性较差,并且不符合规范的要求。因此,不建议在新系统中使用。


化学消毒

化学消毒mainly refers to the disinfection and cleaning of system pipelines by adding purified water with chemical agents.In the new system, chemical agents will be added during chemical disinfection, and the cleaning process after disinfection is complex, expensive, and the residue detection is troublesome. Therefore, it will not be used as the routine disinfection method for purified water system.Chemical cleaning is used as a means of disinfection of the system only after the system has been discontinued for a long time or microbial membranes have formed.